Power consumption would be reduced and cpu resources for other things running on the server would be increased.
The big problem with polling is always how often to poll, poll more often and higher CPU usage, poll less often means having to wait longer for new files to be detected which is rather annoying. Generally polling always means having to wait...using inotify means almost zero wait time which is far better.

You'll need to use a URL of the format - http://hostname:2202/opds-comics